Quick Answer: What Do Aldosterone Antagonists Do?

How can I lower my aldosterone naturally?

Treating hyperaldosteronism focuses on reducing your aldosterone levels or blocking the effects of aldosterone, high blood pressure, and low blood potassium….These include:Eating a healthy diet.


Reducing alcohol and caffeine.

Quitting smoking..

Can too much aldosterone cause weight gain?

Fast-growing tumors sometimes cause the adrenal gland to produce elevated levels of aldosterone, cortisol, and adrenal sex hormones such as androgen. Symptoms of adrenocortical carcinoma—such as high blood pressure, weight gain, and diabetes—can easily be attributed to or confused with many other medical problems.

Does Bendrofluazide cause low potassium?

Bendroflumethiazide does not make asthma worse. However, some medicines used to treat asthma can cause low levels of potassium in your blood, and this is also a side effect of bendroflumethiazide.

Is Bendroflumethiazide potassium sparing?

Thiazide diuretics (for example, bendroflumethiazide).These are mainly used for treating high blood pressure (hypertension) and fluid on the legs (oedema). See the separate leaflet called Thiazide Diuretics for more information. Potassium-sparing diuretics.

What happens when you block aldosterone?

By blocking the effects of aldosterone, aldosterone receptor antagonists block the reabsorption of sodium, which encourages water loss. Consequently, this leads to a decrease in blood pressure and a reduction in fluid around the heart.

What does aldosterone do to the heart?

Beyond blood pressure For example, high aldosterone levels may promote the thickening and scarring of heart muscle tissue, known as cardiac fibrosis. High aldosterone levels also may contribute to coronary microvascular disease, which is characterized by damage to the walls of the small arteries in the heart.

Why is aldosterone an antagonist in heart failure?

Aldosterone antagonists are an important pharmacologic therapy in the neurohormonal blockade necessary in the treatment of systolic heart failure. These drugs have been shown to decrease mortality and reduce hospital readmission rates.

Is Lasix an aldosterone antagonist?

Lasix and Aldactone belong to different drug classes. Lasix is an anthranilic acid derivative used as a strong loop diuretic and Aldactone is an aldosterone receptor antagonist.

What are the effects of aldosterone?

Aldosterone release causes sodium and water retention, which causes increased blood volume, and a subsequent increase in blood pressure, which is sensed by the baroreceptors. To maintain normal homeostasis these receptors also detect low blood pressure or low blood volume, causing aldosterone to be released.

What hormone is antagonistic to aldosterone?

SpironolactoneSpironolactone. Spironolactone is a nonselective aldosterone receptor antagonist that is metabolized extensively in the liver to its active metabolites (Table 1).

What are the symptoms of too much aldosterone?

SymptomsMuscle cramps.Weakness.Fatigue.Headache.Excessive thirst.A frequent need to urinate.

What is the treatment for high aldosterone?

Your doctor may first prescribe spironolactone (Aldactone). This medication helps correct high blood pressure and low potassium, but may cause other problems. In addition to blocking aldosterone receptors, spironolactone may inhibit the action of other hormones.

What are the long term side effects of spironolactone?

30 The most common side effects were diuretic effects (29%), menstrual irregularities (22%), and breast tenderness (17%). 30 The authors concluded that long-term use of spironolactone in the treatment of AV appears to be safe.

Does aldosterone increase blood pressure?

Aldosterone causes an increase in salt and water reabsorption into the bloodstream from the kidney thereby increasing the blood volume, restoring salt levels and blood pressure.

What drugs are aldosterone antagonists?

There are currently two aldosterone antagonists commercially available in the United States, spironolactone and eplerenone. Spironolactone is a nonselective aldosterone antagonist, and eplerenone is selective to the aldosterone receptor.

Are aldosterone antagonists potassium sparing?

Potassium-sparing Diuretics. Aldosterone antagonists (spironolactone, eplerenone) inhibit the action of aldosterone in the collecting duct; as such, these agents cause modest diuresis and natriuresis but inhibit potassium and hydrogen ion secretion.

Is aldosterone a steroid?

Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa.

What drug class is aldosterone?

Aldactone may be used alone or with other medications. Aldactone belongs to a class of drugs called Aldosterone Antagonists, Selective, Diuretics, Potassium-Sparing.