- What type of cells secrete renin?
- What is the function of renin?
- What is the function of mesangial cells?
- Why is renin secreted?
- What are Extraglomerular mesangial cells?
- Which cells of the afferent Arteriole secrete renin?
- Which cells act as mechanoreceptors in the afferent Arteriole and release renin?
- Do mesangial cells secrete renin?
- What is JGA?
- Where is JGA located?
- Does the macula densa secrete renin?
- What activates macula densa?
What type of cells secrete renin?
Specialized granule cells called juxtaglomerular cells or JG cells in the afferent arteriole release renin into the circulation.
Renin is a proteolytic enzyme that converts an inactive plasma protein, an α2 globulin, called angiotensinogen, into angiotensin I.
Angiotensin I is a polypeptide 10 amino acids in length..
What is the function of renin?
Renin, enzyme secreted by the kidney (and also, possibly, by the placenta) that is part of a physiological system that regulates blood pressure. In the blood, renin acts on a protein known as angiotensinogen, resulting in the release of angiotensin I.
What is the function of mesangial cells?
Mesangial cells provide structural support to the glomerular tuft, produce and maintain mesangial matrix, communicate with other glomerular cells by secreting soluble factors, and may contribute to the glomerular capillary flow via their contractile properties.
Why is renin secreted?
Renin’s primary function is therefore to eventually cause an increase in blood pressure, leading to restoration of perfusion pressure in the kidneys. Renin is secreted from juxtaglomerular kidney cells, which sense changes in renal perfusion pressure, via stretch receptors in the vascular walls.
What are Extraglomerular mesangial cells?
Extraglomerular mesangial cells (also known as Lacis cells, Polkissen cells, or Goormaghtigh cells) are light-staining pericytes in the kidney found outside the glomerulus, near the vascular pole.
Which cells of the afferent Arteriole secrete renin?
The juxtaglomerular cells, derived from smooth muscle cells, of the afferent arteriole secrete renin when blood pressure in the arteriole falls. Renin increases blood pressure via the renin-angiotensin-aldosterone system.
Which cells act as mechanoreceptors in the afferent Arteriole and release renin?
The juxtaglomerular cells (JG cells, or granular cells) are cells in the kidney that synthesize, store, and secrete the enzyme renin. They are specialized smooth muscle cells mainly in the walls of the afferent arterioles (and some in the efferent arterioles) that deliver blood to the glomerulus.
Do mesangial cells secrete renin?
Extraglomerular mesangial cells are located in the junction between the afferent and efferent arterioles. These cells have a contractile property similar to vascular smooth muscles and thus play a role in “regulating GFR” by altering the vessel diameter. Renin is also found in these cells.
What is JGA?
juxtaglomerular apparatus (JGA) A region of tissue found in each nephron in the kidney that is important is regulating blood pressure and body fluid and electrolytes. … The JGA also includes chemoreceptor cells of the adjacent region of the distal tubule, which form a tightly packed array called the macula densa.
Where is JGA located?
glomerulusThe JGA is located at the vascular pole of the glomerulus, where a portion of the distal nephron comes into contact with its parent glomerulus.
Does the macula densa secrete renin?
The macula densa participates in the regulation of renin release from juxtaglomerular granular cells. Renin secretion depends on NaCl delivery to and reabsorption by the macula-densa cells at the end of the TAL.
What activates macula densa?
Macula densa cells sense changes in sodium chloride level, and will trigger an autoregulatory response to increase or decrease reabsorption of ions and water to the blood (as needed) in order to alter blood volume and return blood pressure to normal.