What Causes Hyperprolactinemia?

What are the signs of high prolactin?

High Prolactin Level SymptomsInfertility.White milk leaking from nipples.Absent, infrequent, or irregular periods.Loss of libido.Painful or uncomfortable intercourse.Vaginal dryness.Acne.Excessive body and facial hair growth (hirsutism)More items….

What is the normal range of prolactin in female?

Normal Results The normal values for prolactin are: Men: less than 20 ng/mL (425 µg/L) Nonpregnant women: less than 25 ng/mL (25 µg/L) Pregnant women: 80 to 400 ng/mL (80 to 400 µg/L)

Can stress cause high prolactin levels?

Neuroendocrine Changes. There is some evidence that functional hyperprolactinemia may be due to stress-induced neuroendocrine changes of dopamine and serotonin, thus affecting prolactin release [35]. REM sleep rebound, a behavioral coping mechanism to stress, has been found to be mediated by prolactin [36].

How does prolactin affect the body?

Prolactin is a hormone produced by your pituitary gland which sits at the bottom of the brain. Prolactin causes breasts to grow and develop and causes milk to be made after a baby is born. Normally, both men and women have small amounts of prolactin in their blood.

Can exercise reduce prolactin levels?

Of these studies in men, one study reported a significant increase in prolactin concentrations over an eight-week, intensive exercise regimen [18] and two others reported significantly reduced prolactin concentrations associated with intensive exercise among athletes [19,20].

Does turmeric lower prolactin?

The growth-inhibitory effect of curcumin was accompanied by decreased expression of cyclin D3 and ser 780 phosphorylation of retinoblastoma protein. In addition, curcumin also induced apoptosis in both GH3 and MMQ cells. Furthermore, curcumin suppresses intracellular levels and release of both prolactin and GH.

What are the side effects of high prolactin levels?

Symptoms include irregular or absent menstrual periods, infertility, menopausal symptoms (hot flashes and vaginal dryness), and, after several years, osteoporosis (thinning and weakening of the bones). High prolactin levels can also cause milk discharge from the breasts.

How can I get my prolactin levels down?

Treatment for high prolactin levelschanging your diet and keeping your stress levels down.stopping high-intensity workouts or activities that overwhelm you.avoiding clothing that makes your chest uncomfortable.avoiding activities and clothing that overstimulate your nipples.taking vitamin B-6 and vitamin E supplements.

Can prolactin cause weight gain?

Even in men, breast enlargement (gynecomastia) and breast discharge can occur. High levels of prolactin can also result in weight gain and neuropsychological disturbances. The size of the tumor correlates with the amount of prolactin secreted. Larger tumors can cause mass effects by compression of local structures.

What causes high prolactin levels in non pregnant female?

If prolactin levels are higher than normal, it often means there is a type of tumor of the pituitary gland, known as a prolactinoma. This tumor makes the gland produce too much prolactin. Excess prolactin can cause the production of breast milk in men and in women who are not pregnant or breastfeeding.

Can I get pregnant with high prolactin?

High prolactin levels inhibit secretion of FSH, which is the hormone that triggers ovulation. So, if your prolactin levels are high, your ovulation may be suppressed. This is why women who are breastfeeding (and thus have high levels of prolactin) usually don’t become pregnant.

Does prolactin make you emotional?

In contrast, clinical studies in humans have indicated a correlation between high PRL levels and psychological distress. Female patients with hyperprolactinemia usually report more symptoms of anxiety and hostility than control female subjects (24).

Does high prolactin always mean tumor?

What causes hyperprolactinemia? One common cause of hyperprolactinemia is a growth or tumor on the pituitary gland called a prolactinoma. The tumor produces high levels of prolactin. These tumors can be large or small and are usually benign, meaning they are not cancerous.

What can I eat to reduce prolactin?

Foods that lower prolactin levels are generally high in zinc; think shellfish, beef, turkey and beans. It’s also important to get plenty of B6, so foods like potatoes, bananas, wild salmon, chicken and spinach can help boost those vitamin levels.

Can lack of sleep cause high prolactin?

Excess breast manipulation, high protein meals, physical activity and sleep deprivation can artificially elevate the prolactin levels. Rarely, there are brain tumors that block the signals from the hypothalamus to the pituitary gland that can result in elevated prolactin levels.

Does prolactin affect sleep?

Similar to growth hormone secretion, prolactin secretion is more strongly related to sleep onset, although some circadian input occurs. Prolactin levels are associated with slow-wave sleep, and interrupted sleep results in blunting of the nighttime rise.

What causes high levels of prolactin?

Its hormones help regulate important functions such as growth, metabolism, blood pressure and reproduction. Other possible causes of prolactin overproduction include medications, other types of pituitary tumors, an underactive thyroid gland, ongoing irritation to the chest, pregnancy and breast-feeding.

What are the signs and symptoms of hyperprolactinemia?

Symptoms of hyperprolactinemiainfertility.irregular periods.change in menstrual flow.pause in menstrual cycle.loss of libido.lactation (galactorrhea)pain in breasts.vaginal dryness.